منابع مشابه
Studies on the Isolation of Metaphase Chromosomes
A method for the isolation of metaphase chromosomes from mouse L1210 leukemia cells has been developed. Cells, arrested at metaphase with colchicine, were exposed to hypotonic solution and the pH was then adjusted to 5.6 to stabilize the chromosomes. The metaphase figures were subsequently disrupted and the chromosomes isolated by a series of differential centrifugations in sucrose. The isolate...
متن کاملStudies in Rodent Poliomyelitis
1. The murine virus may be grown in embryonic mouse brain-serum ultrafiltrate cultures. The virus fails to grow in embryonic chick tissue cultures or in fertilized egg preparations. 2. Some relationship can be demonstrated between the amount of nervous tissue and the infectivity of the culture. 3. Optimum titers of virus potency (10(-6)) can be obtained by adjusting the pH of the growing cultur...
متن کاملStudies in Rodent Poliomyelitis
A description has been given of the lesions produced in mice and guinea pigs by inoculation of the Jungeblut-Sanders virus. The histopathological findings, although in themselves not conclusive, would tend to support the opinion that Jungeblut and Sanders have transmitted the SK poliomyelitis virus to mouse and guinea pig. In mice the virus apparently retains its affinity for the anterior horns...
متن کاملDistribution studies on polytene chromosomes using antibodies directed against hnRNP
The distribution of nuclear ribonucleoprotein (hnRNP) particles in Drosophila polytene chromosomes has been investigated using anti-B-36 serum as a probe. The use of polytene chromosomes allows resolution at the level of the chromomere, and provides the opportunity to look for both positive and negative correlations with transcriptional activity. The antiserum was obtained using the nuclear pro...
متن کاملStudies of Thalidomide's Effects on Rodent Embryos from 1962-2008
Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early laboratory tests in rodent populations showed that pregnant rodents could safely use it, so doctors prescribed Thalidomide to treat morning sickness in pregnant women. However, in humans [3] Thalidomide interfered with embryonic and fetal developm...
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ژورنال
عنوان ژورنال: CYTOLOGIA
سال: 1973
ISSN: 0011-4545,1348-7019
DOI: 10.1508/cytologia.38.403